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Impaired renal function and biomarkers of vascular disease in Alzheimer’s disease

journal contribution
posted on 2023-06-08, 16:42 authored by Cassandra Richardson, Ramin Nilforooshan, Paul R Gard, Gary Weaving, Naji TabetNaji Tabet
Renal disease is a risk factor for vascular diseases and for dementia, and renal insufficiency can be a feature of Alzheimer’s disease (AD). Evidence has suggested that vascular mechanisms mediate the link between renal disease and dementia. Our study sought to test this hypothesis by examining renal and vascular functioning in AD by investigating estimated glomerular filtration rates (eGFR), calculated from serum creatinine concentrations, and established biomarkers of vascular functioning, asymmetrical dimethylarginine (ADMA) and plasma homocysteine (Hcy), in individuals with mild to moderate AD (n = 34) and a group of older adult controls (n = 34). We found significantly reduced eGFR, indicative of impaired renal functioning, in individuals with AD (M = 62.9, SD = 15.2) compared with controls (M = 73.6, SD = 11.8). However, concentrations of ADMA and Hcy did not differ between patient and control groups (ADMA: M = 0.47; M = 0.50; Hcy: M = 17.2; M = 14.9; patients and controls). The criteria for a mediation analysis were not met, as concentrations of ADMA and Hcy did not predict AD, indicating that these biomarkers of vascular functioning did not mediate a relationship between renal functioning and AD. This study indicated that renal insufficiency may independently contribute to AD pathology, and other vascular mechanisms may influence a relationship between renal impairment and AD.

History

Publication status

  • Published

File Version

  • Published version

Journal

Current Alzheimer Research

ISSN

1567-2050

Publisher

Bentham Science Publishers

Issue

3

Volume

11

Page range

253-258

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2014-02-12

First Open Access (FOA) Date

2014-02-12

First Compliant Deposit (FCD) Date

2014-02-12

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