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Incorporating Immunotherapy in the Management of Gastric Cancer Molecular and Clinical Implications.pdf (1.39 MB)

Incorporating immunotherapy in the management of gastric cancer: molecular and clinical implications

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posted on 2023-06-10, 05:57 authored by Alessandro AgnarelliAlessandro Agnarelli, Viviana Vella, Mark SamuelsMark Samuels, Panagiotis Papanastasopoulos, Georgios GiamasGeorgios Giamas
Gastric cancer has a median survival of 11 months, and this poor prognosis has not improved over the last 30 years. Recent pre-clinical data suggest that there is high tumour-related neoantigen expression in gastric cancer cells, suggesting that a clinical strategy that enhances the host’s immune system against cancer cells may be a successful approach to improve clinical outcomes. Additionally, there has been an increasing amount of translational evidence highlighting the relevance of PD-L1 expression in gastric cancer cells, indicating that PD-1/PD-L1 inhibitors may be useful. Several molecular subgroups of gastric cancer have been identified to respond with excellent outcomes to immunotherapy, including microsatellite instable tumours, tumours bearing a high tumour mutational burden, and tumours related to a chronic EBV infection. In gastric cancer, immunotherapy has produced durable responses in chemo-refractory patients; however, most recently there has been a lot of enthusiasm as several large-scale clinical trials highlight the improved survival noted from the incorporation of immunotherapy in the first line setting for advanced gastric cancer. Our review aims to discuss current pre-clinical and clinical data supporting the innovative role of immunotherapy in gastric cancer.

History

Publication status

  • Published

File Version

  • Published version

Journal

Cancers

ISSN

2072-6694

Publisher

MDPI AG

Issue

18

Volume

14

Page range

e4378 1-25

Event location

Switzerland

Department affiliated with

  • Biochemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2023-01-12

First Open Access (FOA) Date

2023-01-12

First Compliant Deposit (FCD) Date

2023-01-12

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