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Integrated metastate functional connectivity networks predict change in symptom severity in clinical high risk for psychosis

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journal contribution
posted on 2023-06-10, 04:57 authored by George Gifford, Nicholas Crossley, Sarah Morgan, Matthew J Kempton, Paola Dazzan, Gemma Modinos, Matilda Azis, Carly Samson, Ilaria Bonoldi, Beverly Quinn, Sophie E Smart, Mathilde Antoniades, Mattijis G Bossong, Matthew R Broome, Jesus Perez, Oliver D Howes, James StoneJames Stone, Paul Allen, Anthony A Grace, Philip McGuire
The ability to identify biomarkers of psychosis risk is essential in defining effective preventive measures to potentially circumvent the transition to psychosis. Using samples of people at clinical high risk for psychosis (CHR) and Healthy controls (HC) who were administered a task fMRI paradigm, we used a framework for labelling time windows of fMRI scans as ‘integrated’ FC networks to provide a granular representation of functional connectivity (FC). Periods of integration were defined using the ‘cartographic profile’ of time windows and k-means clustering, and sub-network discovery was carried out using Network Based Statistics (NBS). There were no network differences between CHR and HC groups. Within the CHR group, using integrated FC networks, we identified a sub-network negatively associated with longitudinal changes in the severity of psychotic symptoms. This sub-network comprised brain areas implicated in bottom-up sensory processing and in integration with motor control, suggesting it may be related to the demands of the fMRI task. These data suggest that extracting integrated FC networks may be useful in the investigation of biomarkers of psychosis risk.

History

Publication status

  • Published

File Version

  • Published version

Journal

Human Brain Mapping

ISSN

1065-9471

Publisher

Wiley

Issue

2

Volume

42

Page range

439-451

Event location

United States

Department affiliated with

  • BSMS Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2022-10-03

First Open Access (FOA) Date

2022-10-03

First Compliant Deposit (FCD) Date

2022-09-30