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Interplay between polygenic propensity for ageing-related traits and the consumption of fruits and vegetables on future dementia diagnosis

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posted on 2023-06-10, 03:44 authored by Emma Ruby Francis, Dorina CadarDorina Cadar, Andrew Steptoe, Olesya Ajnakina
Background Understanding how polygenic scores for ageing-related traits interact with diet in determining a future dementia including Alzheimer’s diagnosis (AD) would increase our understanding of mechanisms underlying dementia onset. Methods Using 6784 population representative adults aged =50?years from the English Longitudinal Study of Ageing, we employed accelerated failure time survival model to investigate interactions between polygenic scores for AD (AD-PGS), schizophrenia (SZ-PGS) and general cognition (GC-PGS) and the baseline daily fruit and vegetable intake in association with dementia diagnosis during a 10-year follow-up. The baseline sample was obtained from waves 3–4 (2006–2009); follow-up data came from wave 5 (2010–2011) to wave 8 (2016–2017). Results Consuming

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Publication status

  • Published

File Version

  • Published version

Journal

BMC Psychiatry

ISSN

1471-244X

Publisher

BMC

Issue

1

Volume

22

Page range

1-10

Article number

a75

Event location

England

Department affiliated with

  • BSMS Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2022-05-30

First Open Access (FOA) Date

2022-05-30

First Compliant Deposit (FCD) Date

2022-05-30

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