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Key molecular drivers of chronic lymphocytic leukemia
journal contribution
posted on 2023-06-10, 04:55 authored by Suliman A Alsagaby, Paul Brennan, Christopher PepperChristopher PepperChronic lymphocytic leukemia (CLL) is an adult neoplastic disease of B cells characterized by variable clinical outcomes. Although some patients have an aggressive form of the disease and often encounter treatment failure and short survival, others have more stable disease with long-term survival and little or no need for theraphy. In the past decade, significant advances have been made in our understanding of the molecular drivers that affect the natural pathology of CLL. The present review describes what is known about these key molecules in the context of their role in tumor pathogenicity, prognosis, and therapy.
History
Publication status
- Published
Journal
Clinical Lymphoma, Myeloma and LeukemiaISSN
2152-2650Publisher
Elsevier BVExternal DOI
Issue
11Volume
16Page range
593-606Event location
United StatesDepartment affiliated with
- Clinical and Experimental Medicine Publications
Full text available
- No
Peer reviewed?
- Yes