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Lack of involvement of alpha-synuclein in unconditioned anxiety in mice
journal contribution
posted on 2023-06-07, 18:58 authored by Yolanda Pena-OliverYolanda Pena-Oliver, Vladimir L Buchman, David N StephensAlpha-synuclein is implicated in the pathology of Parkinson disease (PD) and is involved in synaptic function, particularly in presynaptic events in dopamine (DA) synapses. Recently, a role for alpha-synuclein in reward and addiction, especially in alcoholism, has been reported. Since PD and alcohol dependence present a strong comorbidity with anxiety disorders, a role for alpha-synuclein in anxiety has been proposed. The aim of the present investigation was to study the involvement of alpha-synuclein in anxiety by testing alpha-synuclein knock out and wild type mice in three different emotionality tests: the open field, the elevated plus maze and the light¿dark box. Alpha-synuclein knock out mice and wild type controls displayed consistently similar emotionality profiles in all the tests, suggesting a lack of involvement of alpha-synuclein in unconditioned anxiety in mice.
History
Publication status
- Published
Journal
Behavioural Brain ResearchISSN
0166-4328External DOI
Issue
2Volume
209Page range
234-240Pages
8.0Department affiliated with
- Psychology Publications
Full text available
- No
Peer reviewed?
- Yes