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Lead diversification 2: application to P38, gMTP and lead compounds
journal contribution
posted on 2023-06-08, 20:55 authored by M Abid Masood, Marc Bazin, Mark E Bunnage, Andrew Calabrese, Mark Cox, Sally-Ann Fancy, Elizabeth Farrant, David W Pearce, Manuel Perez, Laure Hitzel, Torren PeakmanLead Diversification is a new technology platform developed at Pfizer for the functionalization of drug molecules using C–H activation. We describe its application to some drug programs such as P38 and gMTP and the development of some new plate based screens including a fluorination screen.
History
Publication status
- Published
Journal
Bioorganic and Medicinal Chemistry LettersISSN
0960-894XPublisher
ElsevierExternal DOI
Issue
2Volume
22Page range
1255-1262Department affiliated with
- Chemistry Publications
Full text available
- No
Peer reviewed?
- Yes