Lead diversification 2: application to P38, gMTP and lead compounds

Masood, M Abid; Bazin, Marc; Bunnage, Mark E; Calabrese, Andrew; Cox, Mark; Fancy, Sally-Ann; Farrant, Elizabeth; Pearce, David W; Perez, Manuel; Hitzel, Laure; Peakman, Torren

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Lead diversification 2: application to P38, gMTP and lead compounds

journal contribution

posted on 2023-06-08, 20:55 authored by M Abid Masood, Marc Bazin, Mark E Bunnage, Andrew Calabrese, Mark Cox, Sally-Ann Fancy, Elizabeth Farrant, David W Pearce, Manuel Perez, Laure Hitzel, Torren Peakman

Lead Diversification is a new technology platform developed at Pfizer for the functionalization of drug molecules using C–H activation. We describe its application to some drug programs such as P38 and gMTP and the development of some new plate based screens including a fluorination screen.

History

Publication status

Published

Journal

Bioorganic and Medicinal Chemistry Letters

ISSN

0960-894X

Publisher

Elsevier

External DOI

https://doi.org/10.1016/j.bmcl.2011.11.033

Issue

2

Volume

22

Page range

1255-1262

Department affiliated with

Chemistry Publications

Full text available

No

Peer reviewed?

Yes

Legacy Posted Date

2015-06-01

File(s) not publicly available

Lead diversification 2: application to P38, gMTP and lead compounds

History

Publication status

Journal

ISSN

Publisher

External DOI

Issue

Volume

Page range

Department affiliated with

Full text available

Peer reviewed?

Legacy Posted Date

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