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Lead diversification 2: application to P38, gMTP and lead compounds

journal contribution
posted on 2023-06-08, 20:55 authored by M Abid Masood, Marc Bazin, Mark E Bunnage, Andrew Calabrese, Mark Cox, Sally-Ann Fancy, Elizabeth Farrant, David W Pearce, Manuel Perez, Laure Hitzel, Torren Peakman
Lead Diversification is a new technology platform developed at Pfizer for the functionalization of drug molecules using C–H activation. We describe its application to some drug programs such as P38 and gMTP and the development of some new plate based screens including a fluorination screen.

History

Publication status

  • Published

Journal

Bioorganic and Medicinal Chemistry Letters

ISSN

0960-894X

Publisher

Elsevier

External DOI

Issue

2

Volume

22

Page range

1255-1262

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2015-06-01

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    University of Sussex (Publications)

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