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Lead diversification 2: application to P38, gMTP and lead compounds
journal contributionposted on 2023-06-08, 20:55 authored by M Abid Masood, Marc Bazin, Mark E Bunnage, Andrew Calabrese, Mark Cox, Sally-Ann Fancy, Elizabeth Farrant, David W Pearce, Manuel Perez, Laure Hitzel, Torren Peakman
Lead Diversification is a new technology platform developed at Pfizer for the functionalization of drug molecules using C–H activation. We describe its application to some drug programs such as P38 and gMTP and the development of some new plate based screens including a fluorination screen.
JournalBioorganic and Medicinal Chemistry Letters
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- Chemistry Publications
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