University of Sussex
GAYSINA_Longitudinal_and_Life_Course_Studies_MAR_2022.pdf (199.43 kB)

Life course trajectories of affective symptoms and their early life predictors

Download (199.43 kB)
journal contribution
posted on 2023-06-10, 03:27 authored by Ellen J Thompson, George B Ploubidis, Marcus Richards, Darya GaysinaDarya Gaysina
Background: Life course trajectories of affective symptoms (i.e., depression and anxiety) are heterogenous. However, few studies have investigated the role of early life risk factors in the development of these trajectories. The present study aimed to: 1) derive latent trajectories of affective symptoms over a period of more than 50 years (from age 13 through age 69), and 2) examine early life risk factors for associations with specific life course trajectories of affective symptoms. Method: Participants are from the MRC National Survey of Health and Development (NSHD) (n = 5362). Affective symptoms were measured prospectively at ages 13, 15, 36, 43, 53, 60-64 and 69. A latent variable modelling framework was implemented to model longitudinal profiles of affective symptoms. Twenty-four prospectively measured early life predictors were tested for associations with different symptom profiles using multinomial logistic regression. Results: Four life course profiles of affective symptoms were identified: 1) absence of symptoms (66.6% of the sample); 2) adolescent symptoms with good adult outcome (15.2%); 3) adult symptoms only (with no symptoms in adolescence and late life) (12.9%); 4) symptoms in adolescence and mid adulthood (5.2%). Of the twenty-four early life predictors observed, only four were associated with life course trajectories, with small effect sizes observed. Conclusions: People differ in their life course trajectories of anxiety and depression symptoms and that these differences are not largely influenced by early life factors tested in this study.


Publication status

  • Published

File Version

  • Accepted version


Longitudinal and Life Course Studies




Bristol University Press





Page range


Department affiliated with

  • Psychology Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date


First Compliant Deposit (FCD) Date


Usage metrics

    University of Sussex (Publications)


    No categories selected