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May the 4C's be with you: an overview of complexity-inspired frameworks for analysing resting-state neuroimaging data

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posted on 2023-06-10, 06:22 authored by Fran Hancock, Fernando Ernesto Rosas De AndracaFernando Ernesto Rosas De Andraca, Pedro A M Mediano, Andrea I Luppi, Joanna Cabral, Ottavia Dipasquale, Federico E Turkheimer
Competing and complementary models of resting-state brain dynamics contribute to our phenomenological and mechanistic understanding of whole-brain coordination and communication, and provide potential evidence for differential brain functioning associated with normal and pathological behaviour. These neuroscientific theories stem from the perspectives of physics, engineering, mathematics and psychology and create a complicated landscape of domain-specific terminology and meaning, which, when used outside of that domain, may lead to incorrect assumptions and conclusions within the neuroscience community. Here, we review and clarify the key concepts of connectivity, computation, criticality and coherence-the 4C's-and outline a potential role for metastability as a common denominator across these propositions. We analyse and synthesize whole-brain neuroimaging research, examined through functional magnetic imaging, to demonstrate that complexity science offers a principled and integrated approach to describe, and potentially understand, macroscale spontaneous brain functioning.

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Publication status

  • Published

File Version

  • Published version

Journal

Journal of the Royal Society Interface

ISSN

1742-5689

Publisher

The Royal Society

Issue

191

Volume

19

Page range

1-14

Event location

England

Department affiliated with

  • Informatics Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2023-03-02

First Open Access (FOA) Date

2023-03-02

First Compliant Deposit (FCD) Date

2023-03-01

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