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Model studies for the synthesis of galbonolide B
journal contribution
posted on 2023-06-07, 22:05 authored by James Eshelby, Matthias Goessmann, Philip J Parsons, Lewis Pennicott, Adrian HightonThe construction of the fourteen membered ring present in galbonolide B 1 is reported. The 10,11-diene system present in the southern portion of 1 has been constructed using an ester enolate rearrangement/ silicon mediated fragmentation cascade, whilst the macrocycle has been synthesised following a Johnson rearrangement/ mercury assisted ring closure protocol.
History
Publication status
- Published
Journal
Organic and Biomolecular ChemistryISSN
1477-0520Publisher
Royal Society of ChemistryExternal DOI
Issue
16Volume
3Page range
2994-2997Pages
4.0Department affiliated with
- Chemistry Publications
Notes
Synthetic work carried at Sussex and directed by the principle author PJP also involved, two industrial collaborators as co authors. A novel approach to the synthesis of galbonolide B.Full text available
- No
Peer reviewed?
- Yes
