Goff_Applied Sciences Review_2020.pdf (639.93 kB)
Multi-omics technologies applied to tuberculosis drug discovery
journal contribution
posted on 2023-06-07, 07:35 authored by Aaron Goff, Daire Cantillon, Leticia Murano Wildner, Simon WaddellSimon WaddellMulti-omics strategies are indispensable tools in the search for new anti-tuberculosis drugs. Omics methodologies, where the ensemble of a class of biological molecules are measured and evaluated together, enable drug discovery programs to answer two fundamental questions. Firstly, in a discovery biology approach, to find new targets in druggable pathways for target-based investigation, advancing from target to lead compound. Secondly, in a discovery chemistry approach, to identify the mode of action of lead compounds derived from high-throughput screens, progressing from compound to target. The advantage of multi-omics methodologies in both of these settings is that omics approaches are unsupervised and unbiased to a priori hypotheses, making omics useful tools to confirm drug action, reveal new insights into compound activity, and discover new avenues for inquiry. This review summarizes the application of Mycobacterium tuberculosis omics technologies to the early stages of tuberculosis antimicrobial drug discovery.
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Publication status
- Published
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- Published version
Journal
Applied SciencesISSN
2076-3417Publisher
MDPIExternal DOI
Issue
13Volume
10Page range
1-20Article number
a4629Department affiliated with
- Global Health and Infection Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2020-07-22First Open Access (FOA) Date
2020-07-22First Compliant Deposit (FCD) Date
2020-07-22Usage metrics
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