N1-arylation of 1,4-benzodiazepine-2-ones with diaryliodonium salts

Khan, Raysa; Felix, Robert; Kemmitt, Paul D; Coles, Simon J; Tizzard, Graham J; Spencer, John

N1-arylation of 1,4-benzodiazepine-2-ones with diaryliodonium salts

journal contribution

posted on 2023-06-12, 08:43 authored by Raysa Khan, Robert Felix, Paul D Kemmitt, Simon J Coles, Graham J Tizzard, John SpencerJohn Spencer

A library of N1-arylated 5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-ones has been synthesized starting with unsymmetrical diaryliodonium salts using aqueous ammonia as a base. This can also be applied to a similar 1,3,4-benzotriazepin-2-one derivative.

Funding

A Precompetitive Modular Peptidomimetic Toolkit for Targeting PPIs iCASE; G1436; EPSRC-ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL; EP/M507568/1

History

Publication status

Published

File Version

Published version

Journal

Synlett

ISSN

0936-5214

Publisher

Georg Thieme Verlag

External DOI

https://doi.org/10.1055/s-0036-1590920

Issue

02

Volume

29

Page range

193-198

Department affiliated with

Chemistry Publications

Full text available

Yes

Peer reviewed?

Yes

Legacy Posted Date

2017-09-07

First Open Access (FOA) Date

2017-10-19

First Compliant Deposit (FCD) Date

2017-09-06

N1-arylation of 1,4-benzodiazepine-2-ones with diaryliodonium salts

Funding

A Precompetitive Modular Peptidomimetic Toolkit for Targeting PPIs iCASE; G1436; EPSRC-ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL; EP/M507568/1

History

Publication status

File Version

Journal

ISSN

Publisher

External DOI

Issue

Volume

Page range

Department affiliated with

Full text available

Peer reviewed?

Legacy Posted Date

First Open Access (FOA) Date

First Compliant Deposit (FCD) Date

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