raysa synlett final open access 2018 published.pdf (1.27 MB)
N1-arylation of 1,4-benzodiazepine-2-ones with diaryliodonium salts
journal contribution
posted on 2023-06-12, 08:43 authored by Raysa Khan, Robert Felix, Paul D Kemmitt, Simon J Coles, Graham J Tizzard, John SpencerJohn SpencerA library of N1-arylated 5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-ones has been synthesized starting with unsymmetrical diaryliodonium salts using aqueous ammonia as a base. This can also be applied to a similar 1,3,4-benzotriazepin-2-one derivative.
Funding
A Precompetitive Modular Peptidomimetic Toolkit for Targeting PPIs iCASE; G1436; EPSRC-ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL; EP/M507568/1
History
Publication status
- Published
File Version
- Published version
Journal
SynlettISSN
0936-5214Publisher
Georg Thieme VerlagExternal DOI
Issue
02Volume
29Page range
193-198Department affiliated with
- Chemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes