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N1-arylation of 1,4-benzodiazepine-2-ones with diaryliodonium salts

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journal contribution
posted on 2023-06-12, 08:43 authored by Raysa Khan, Robert Felix, Paul D Kemmitt, Simon J Coles, Graham J Tizzard, John SpencerJohn Spencer
A library of N1-arylated 5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-ones has been synthesized starting with unsymmetrical diaryliodonium salts using aqueous ammonia as a base. This can also be applied to a similar 1,3,4-benzotriazepin-2-one derivative.

Funding

A Precompetitive Modular Peptidomimetic Toolkit for Targeting PPIs iCASE; G1436; EPSRC-ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL; EP/M507568/1

History

Publication status

  • Published

File Version

  • Published version

Journal

Synlett

ISSN

0936-5214

Publisher

Georg Thieme Verlag

External DOI

Issue

02

Volume

29

Page range

193-198

Department affiliated with

  • Chemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-09-07

First Open Access (FOA) Date

2017-10-19

First Compliant Deposit (FCD) Date

2017-09-06

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    Licence

    CC BY 4.0

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