Alz Dem Diag Ass Dis Mo - 2022 - Balouch - Night%E2%80%90to%E2%80%90night variation in sleep associates with day%E2%80%90to%E2%80%90day variation in.pdf (2.73 MB)
Night-to-night variation in sleep associates with day-to-day variation in vigilance, cognition, memory, and behavioral problems in Alzheimer's disease
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posted on 2023-06-15, 20:40 authored by Sara Balouch, Dylan A D Dijk, Jennifer Rusted, Simon S Skene, Naji TabetNaji Tabet, Derk-Jan DijkIntroduction Sleep disturbances are commonly reported in people living with Alzheimer's disease (AD), but it is currently unknown whether night-to-night variation in sleep predicts day-to-day variation in vigilance, cognition, mood, and behavior (daytime measures). Methods Subjective and objective sleep and daytime measures were collected daily for 2 weeks in 15 participants with mild AD, eight participants with mild cognitive impairment (MCI), and 22 participants with no cognitive impairment (NCI). Associations between daytime measures and four principal components of sleep (duration, quality, continuity, and latency) were quantified using mixed-model regression. Results Sleepiness, alertness, contentedness, everyday memory errors, serial subtraction, and behavioral problems were predicted by at least one of the components of sleep, and in particular sleep duration and continuity. Associations between variations in sleep and daytime measures were linear or quadratic and often different between participants with AD and those with NCI. Discussion These findings imply that daytime functioning in people with AD may be improved by interventions that target sleep continuity.
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Publication status
- Published
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- Published version
Journal
Alzheimer's & Dementia: Diagnosis, Assessment & Disease MonitoringISSN
2352-8729Publisher
WileyExternal DOI
Issue
1Volume
14Article number
e12303Event location
United StatesDepartment affiliated with
- BSMS Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-07-13First Open Access (FOA) Date
2022-07-13First Compliant Deposit (FCD) Date
2022-07-13Usage metrics
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