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Nitric oxide in septic shock
journal contribution
posted on 2023-06-08, 06:06 authored by Michael TitheradgeSeptic shock is a major cause of death following trauma and is a persistent problem in surgical patients throughout the world. It is characterised by hypotension and vascular collapse, with a failure of the major organs within the body. The role of excessive nitric oxide (NO) production, following the cytokine-dependent induction of the inducible nitric oxide synthase (iNOS), in the development of septic shock is discussed. Emphasis is placed upon the signal-transduction process by which iNOS is induced and the role of NO in cellular energy dysfunction and the abnormal function of the cardiovascular system and liver during septic shock.
History
Publication status
- Published
Journal
BBA - BioenergeticsISSN
0005-2728Publisher
ElsevierExternal DOI
Issue
2-3Volume
1411Page range
437-455ISBN
0006-3002Department affiliated with
- Biochemistry Publications
Notes
Invited review in special issue on Nitric Oxide BiochemistryFull text available
- No
Peer reviewed?
- Yes