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Nuclear survivin has reduced stability and is not cytoprotective
journal contribution
posted on 2023-06-07, 14:58 authored by Claire M. Connell, Rita Colnaghi, Sally P. WheatleySurvivin is an essential mitotic protein that is overexpressed in many cancers, and its presence is correlated with increased resistance to radiation and chemotherapy. Here we demonstrate that sending survivin into the nucleus accelerates its degradation in a cdh1-dependent manner, abolishes the radio resistance normally conferred to cells by its overexpression, and prevents survivin from inhibiting apoptosis without affecting its mitotic localization. Our data suggest that targeting survivin to the nucleus provides an efficient means of eliminating it from the cell and may prove a novel strategy in cancer treatment, particularly in combination with radiotherapy.
History
Publication status
- Published
Journal
Journal of Biological ChemistryISSN
0021-9258Publisher
American Society for Biochemistry and Molecular BiologyPublisher URL
External DOI
Issue
6Volume
238Page range
3289-3296Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
Notes
Endnotes Ref: GDSC280Full text available
- Yes
Peer reviewed?
- Yes