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On-chip time-correlated fluorescence lifetime extraction algorithms and error analysis

journal contribution
posted on 2023-06-07, 23:53 authored by Day-Uei Li, Eleanor Bonnist, David Renshaw, Robert Henderson
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Publication status

  • Published


Journal of the Optical Society of America A



Department affiliated with

  • Engineering and Design Publications


The theory and application of the Integral Equation Method (IEM) in an innovative non-iterative fluorescence lifetime sensing algorithm, is presented. The IEM allows direction calculations and can be integrated on-chip with sensors, advantageous when compared to lifetime based sensing systems using iterative-based algorithms, for example least square methods. Insensitivity to background noise means when integrated with higher dark count; or with low noise sensors in extremely low light conditions, the IEM algorithm is very powerful. The IEM has been adopted in the large CMOS single-photon avalanche diode (SPAD) sensors of Professor Edoardo Charbon. Contact: Professor Edoardo Charbon, University of Delft, Tel: +31-15-278-3667, Email:

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