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One ring to bring them all--the role of Ku in mammalian non-homologous end joining
journal contributionposted on 2023-06-08, 22:34 authored by Gabrielle J Grundy, Hayley A Moulding, Keith CaldecottKeith Caldecott, Stuart L Rulten
The repair of DNA double strand breaks is essential for cell survival and several conserved pathways have evolved to ensure their rapid and efficient repair. The non-homologous end joining pathway is initiated when Ku binds to the DNA break site. Ku is an abundant nuclear heterodimer of Ku70 and Ku80 with a toroidal structure that allows the protein to slide over the broken DNA end and bind with high affinity. Once locked into placed, Ku acts as a tool-belt to recruit multiple interacting proteins, forming one or more non-homologous end joining complexes that act in a regulated manner to ensure efficient repair of DNA ends. Here we review the structure and functions of Ku and the proteins with which it interacts during non-homologous end joining.
Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
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