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Operationalisation of intrinsic capacity in older people and its association with subsequent disability, hospital admission and mortality: results from ELSA

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posted on 2023-06-10, 06:03 authored by Charlotte L Campbell, Dorina CadarDorina Cadar, Anne McMunn, Paola Zaninotto
Background Intrinsic capacity (IC) is a new concept in the healthy aging field and has many operationalized definitions. In this study, we operationalized IC using item response theory in the English Longitudinal Study of Ageing (ELSA) and tested the predictive value of the scale using a subsequent functional ability, mortality, and hospital admission. Methods IC was measured at baseline (2004, Wave 2) using 14 dichotomous indicators: word recall, orientation in time, balance, chair rises, walking speed, upper mobility, lower mobility, eyesight, hearing, grip strength, body mass index, waist circumference, depressive symptoms, and life satisfaction. A 2-parameter item response theory model was used to generate a scale of IC at baseline. Logistic regression was used for the prediction of subsequent difficulties, measured by difficulties with =1 activities of daily living (ADLs) and =1 instrumental activities of daily living (IADLs) at 4 and 8 years after baseline. Competing risk and Cox regressions were employed to test the prediction of hospital admission and mortality, respectively, over a 14-year follow-up. Results IC scores were generated for 4 545 individuals aged on average 70.8 years (standard deviation [SD] 7.93). Better baseline IC scores were associated with reduced risk of subsequent difficulties with ADLs and IADLs, hospital admission (subdistribution hazard ratios [SHR] = 0.99, 95% confidence interval [CI] 0.98–0.99), and mortality (hazard ratios [HR] = 0.98, 95% CI 0.98–0.99), when adjusted for sociodemographic and health-related covariates. Conclusion These results suggest the utility of this IC score as a measure of risk for future adverse outcomes in older people, potentially above that indicated by other sociodemographic and health-related factors.

History

Publication status

  • Published

File Version

  • Published version

Journal

The Journals of Gerontology: Series A

ISSN

1079-5006

Publisher

Oxford University Press (OUP)

Page range

glac250 1-6

Event location

United States

Department affiliated with

  • BSMS Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2023-01-24

First Open Access (FOA) Date

2023-01-24

First Compliant Deposit (FCD) Date

2023-01-24

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