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Outer hair cell somatic, not hair bundle, motility is the basis of the cochlear amplifier
journal contributionposted on 2023-06-08, 06:20 authored by Marcia M Mellado Lagarde, Markus Drexl, Victoria A Lukashkina, Andrei N Lukashkin, Ian J Russell
Sensitivity, dynamic range and frequency tuning of the cochlea are attributed to amplification involving outer hair cell stereocilia and/or somatic motility. We measured acoustically and electrically elicited basilar membrane displacements from the cochleae of wild-type and TectaDeltaENT/DeltaENT mice, in which stereocilia are unable to contribute to amplification near threshold. Electrically elicited responses from TectaDeltaENT/DeltaENT mice were markedly similar to acoustically and electrically elicited responses from wild-type mice. We conclude that somatic, and not stereocilia, motility is the basis of cochlear amplification.
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