Vera_et_al-2017-European_Journal_of_Nuclear_Medicine_and_Molecular_Imaging.pdf (1.16 MB)
Download filePET brain imaging in HIV-associated neurocognitive disorders (HAND) in the era of combination antiretroviral therapy
journal contribution
posted on 2023-06-09, 04:35 authored by Jaime Vera RojasJaime Vera Rojas, Basil Ridha, Yvonne Gilleece, Aliza Amlani, Patrick Thorburn, Sabina DizdarevicEffective combination antiretroviral therapy (cART) has lead to a significant reduction in the prevalence and incidence of central nervous system (CNS) HIV-associated brain disease, particularly CNS opportunistic infections and HIV encephalitis. Despite this, cognitive deficits in people living with HIV, also known as HIV-associated neurocognitive disorders (HAND) have become more prevalent in recent years. The pathogenesis of HAND is likely to be multifactorial, however recent evidence suggests that brain microglial activation is the most likely pathogenic mechanism. Recent developments in positron emission tomography (PET) brain neuroimaging using novel brain radioligands targeting a variety of physiological changes in the brains of HIV-positive individuals have improved our understanding of the mechanisms associated with the development of HAND. This review will highlight recent PET brain neuroimaging studies in the cART era, focusing on physiological and neurochemical changes associated with HAND in people living with HIV.
History
Publication status
- Published
File Version
- Published version
Journal
European Journal of Nuclear Medicine and Molecular ImagingISSN
1619-7070Publisher
Springer VerlagExternal DOI
Issue
5Volume
44Page range
895-902Department affiliated with
- Global Health and Infection Publications
Full text available
- Yes
Peer reviewed?
- Yes