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Pattern recognition receptors as potential therapeutic targets in inflammatory rheumatic disease

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posted on 2023-06-08, 22:15 authored by Lisa MullenLisa Mullen, Giselle Chamberlain, Sandra SacreSandra Sacre
The pattern recognition receptors of the innate immune system are part of the first line of defence against pathogens. However, they also have the ability to respond to danger signals that are frequently elevated during tissue damage and at sites of inflammation. Inadvertent activation of pattern recognition receptors has been proposed to contribute to the pathogenesis of many conditions including inflammatory rheumatic diseases. Prolonged inflammation most often results in pain and damage to tissues. In particular, the Toll-like receptors and nucleotide-binding oligomerisation domain-like receptors that form inflammasomes have been postulated as key contributors to the inflammation observed in rheumatoid arthritis, osteoarthritis, gout and systemic lupus erythematosus. As such, there is increasing interest in targeting these receptors for therapeutic treatment in the clinic. Here the role of pattern recognition receptors in the pathogenesis of these diseases is discussed, with an update on the development of interventions to modulate the activity of these potential therapeutic targets.

History

Publication status

  • Published

File Version

  • Published version

Journal

Arthritis Research & Therapy

ISSN

1478-6362

Publisher

BioMed Central

Issue

1

Volume

17

Page range

122

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2015-08-28

First Open Access (FOA) Date

2015-08-28

First Compliant Deposit (FCD) Date

2015-08-28

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