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Potential use of modulators of oxidative stress as add-on therapy in patients with anxiety disorders
journal contribution
posted on 2023-06-09, 07:16 authored by Paolo Boldrini, Antonella Fusco, Ferdinando Nicoletti, Aldo Badiani, Luciano SasoIt is known that an increased oxidative stress is present in a wide range of diseases and, given the vulnerability of the central nervous system, its involvement has been in particular investigated in neurological and psychiatric diseases, including anxiety disorders. In this review we analyse the studies that have been conducted on the effects of oxidative stress modulators in anxiety, focusing on their possible clinical use. While preclinical studies have shown a clear anxiolytic-like effect of different oxidative stress modulators, less significant results have been obtained from clinical studies. After having reviewed the possible reasons for the discrepancy between preclinical and clinical data, we encourage further studies aimed at better investigating the utility of the modulation of oxidative stress in humans, as adjunctive therapy of the traditional integrated psychotherapeutic and pharmacological approach.
History
Publication status
- Published
File Version
- Accepted version
Journal
Current Drug TargetsISSN
1389-4501Publisher
Bentham Science PublishersIssue
6Volume
19Department affiliated with
- Psychology Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2017-07-19First Open Access (FOA) Date
2018-04-25First Compliant Deposit (FCD) Date
2017-07-19Usage metrics
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