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Predicting progression in primary progressive multiple sclerosis: a 10-year multicenter study
journal contributionposted on 2023-06-08, 12:51 authored by Zhaleh Khaleeli, Olga Ciccarelli, Francesco Manfredonia, Frederik Barkhof, Bruno Brochet, Mara Cercignani, Vincent Dousset, Massimo Filippi, Xavier Montalban, Chris Polman, Marco Rovaris, Alex Rovira, Jaume Sastre-Garriga, Machteld Vellinga, David Miller, Alan Thompson
Rates of progression vary widely in primary progressive multiple sclerosis. This multicenter study aimed to identify predictors of progression over 10 years. A total of 101 patients who had been imaged at baseline and 2 years were scored on the expanded disability status scale after 10 years. Ordinal logistic regression identified the following independent variables that predicted progression: male sex, shorter disease duration, and slower timed walk test at baseline (best overall predictor), and deterioration in expanded disability status scale score and reduction in brain volume over 2 years. These predictors of long-term disability provide some insight into disease progression.
JournalAnnals of Neurology
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- Clinical and Experimental Medicine Publications
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