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Presynaptic partner selection during retinal circuit reassembly varies with timing of neuronal regeneration in vivo

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posted on 2023-06-09, 20:56 authored by Takeshi YoshimatsuTakeshi Yoshimatsu, Florence D D'Orazi, Clare R Gamlin, Sachihiro C Suzuki, Arminda Suli, David Kimelman, David W Raible, Rachel O Wong
Whether neurons can restore their original connectivity patterns during circuit repair is unclear. Taking advantage of the regenerative capacity of zebrafish retina, we show here the remarkable specificity by which surviving neurons reassemble their connectivity upon regeneration of their major input. H3 horizontal cells (HCs) normally avoid red and green cones, and prefer ultraviolet over blue cones. Upon ablation of the major (ultraviolet) input, H3 HCs do not immediately increase connectivity with other cone types. Instead, H3 dendrites retract and re-extend to contact new ultraviolet cones. But, if regeneration is delayed or absent, blue-cone synaptogenesis increases and ectopic synapses are made with red and green cones. Thus, cues directing synapse specificity can be maintained following input loss, but only within a limited time period. Further, we postulate that signals from the major input that shape the H3 HC's wiring pattern during development persist to restrict miswiring after damage.

History

Publication status

  • Published

File Version

  • Published version

Journal

Nature Communications

ISSN

2041-1723

Publisher

Nature Research

Volume

7

Page range

10590

Event location

England

Department affiliated with

  • Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2020-03-24

First Open Access (FOA) Date

2020-03-24

First Compliant Deposit (FCD) Date

2020-03-24

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