PrimPol-Prime Time to Reprime.pdf (2.79 MB)
Primpol—prime time to reprime
journal contributionposted on 2023-06-10, 00:43 authored by Thomas A Guilliam, Aidan DohertyAidan Doherty
The complex molecular machines responsible for genome replication encounter many obstacles during their progression along DNA. Tolerance of these obstructions is critical for efficient and timely genome duplication. In recent years, primase-polymerase (PrimPol) has emerged as a new player involved in maintaining eukaryotic replication fork progression. This versatile replicative enzyme, a member of the archaeo-eukaryotic primase (AEP) superfamily, has the capacity to perform a range of template-dependent and independent synthesis activities. Here, we discuss the emerging roles of PrimPol as a leading strand repriming enzyme and describe the mechanisms responsible for recruiting and regulating the enzyme during this process. This review provides an overview and update of the current PrimPol literature, as well as highlighting unanswered questions and potential future avenues of investigation.
- Published version
Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
Full text available