PrimPol-Prime Time to Reprime.pdf (2.79 MB)
Primpol—prime time to reprime
journal contribution
posted on 2023-06-10, 00:43 authored by Thomas A Guilliam, Aidan DohertyAidan DohertyThe complex molecular machines responsible for genome replication encounter many obstacles during their progression along DNA. Tolerance of these obstructions is critical for efficient and timely genome duplication. In recent years, primase-polymerase (PrimPol) has emerged as a new player involved in maintaining eukaryotic replication fork progression. This versatile replicative enzyme, a member of the archaeo-eukaryotic primase (AEP) superfamily, has the capacity to perform a range of template-dependent and independent synthesis activities. Here, we discuss the emerging roles of PrimPol as a leading strand repriming enzyme and describe the mechanisms responsible for recruiting and regulating the enzyme during this process. This review provides an overview and update of the current PrimPol literature, as well as highlighting unanswered questions and potential future avenues of investigation.
History
Publication status
- Published
File Version
- Published version
Journal
GenesISSN
2073-4425Publisher
MDPIExternal DOI
Issue
1Volume
8Page range
1-25Article number
a20Event location
SwitzerlandDepartment affiliated with
- Sussex Centre for Genome Damage Stability Publications
Full text available
- Yes
Peer reviewed?
- Yes