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Ras gene in marine mussels: A molecular level response to petrochemical exposure.
journal contributionposted on 2023-06-07, 22:22 authored by I Lima, Mika PeckMika Peck, J Rendón-Von Osten, A M V M Soares, L Guilhermino, J M Rotchell
Mussels are susceptible to numerous toxicants and are often employed as bioindicators. This study investigated the status of the ras proto-oncogene in Mytilus galloprovincialis following petrochemical exposure. A M. galloprovincialis homologue of the vertebrate ras gene was isolated, showing conserved sequence in regions of functional importance and a high incidence of polymorphic variation. Mutational damage was investigated in mussels chronically exposed to the water-accommodated fraction of #4 fuel-oil (WAF), and in mussels collected along the NW coast of Portugal in sites with different levels of petrochemical contamination. A ras gene point mutation was identified in the codon 35 of one individual exposed to 12.5% WAF. No mutations were detected in mussels from the WAF control or environmental samples. This represents the first report of a ras gene mutation, experimentally-induced by petrochemical exposure, in an invertebrate species.
JournalMarine Pollution Bulletin
Department affiliated with
- Evolution, Behaviour and Environment Publications
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