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Reconstituting immune surveillance in breast cancer: molecular pathophysiology and current immunotherapy strategies

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posted on 2023-06-10, 02:23 authored by Chiara Cilibrasi, Panagiotis Papanastasopoulos, Mark SamuelsMark Samuels, Georgios GiamasGeorgios Giamas
Over the past 50 years, breast cancer immunotherapy has emerged as an active field of research, generating novel, targeted treatments for the disease. Immunotherapies carry enormous potential to improve survival in breast cancer, particularly for the subtypes carrying the poorest prognoses. Here, we review the mechanisms by which cancer evades immune destruction as well as the history of breast cancer immunotherapies and recent developments, including clinical trials that have shaped the treatment of the disease with a focus on cell therapies, vaccines, checkpoint inhibitors, and oncolytic viruses.

History

Publication status

  • Published

File Version

  • Published version

Journal

International Journal of Molecular Sciences

ISSN

1661-6596

Publisher

MDPI

Issue

21

Volume

22

Page range

1-20

Article number

a12015

Department affiliated with

  • Biochemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2022-01-20

First Open Access (FOA) Date

2022-01-20

First Compliant Deposit (FCD) Date

2022-01-20

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