regulatory-mechanisms-of-hsp90.pdf (506.16 kB)
Regulatory mechanisms of Hsp90
journal contribution
posted on 2023-06-09, 01:30 authored by Chrisostomos ProdromouChrisostomos ProdromouThe ability of Hsp90 to activate a disparate clientele implicates this chaperone in diverse biological processes. To accommodate such varied roles, Hsp90 requires a variety of regulatory mechanisms that are coordinated in order to modulate its activity appropriately. Amongst these, the master-regulator heat shock factor 1 (HSF1) is critically important in upregulating Hsp90 during stress, but is also responsible, through interaction with specific transcription factors (such as STAT1 and Strap/p300) for the integration of a variety of biological signals that ultimately modulate Hsp90 expression. Additionally, transcription factors, such as STAT1, STAT3 (including STAT1-STAT3 oligomers), NF-IL6, and NF-kB, are known to influence Hsp90 expression directly. Co-chaperones offer another mechanism for Hsp90 regulation, and these can modulate the chaperone cycle appropriately for specific clientele. Co-chaperones include those that deliver specific clients to Hsp90, and others that regulate the chaperone cycle for specific Hsp90-client complexes by modulating Hsp90s ATPase activity. Finally, post-translational modification (PTM) of Hsp90 and its co-chaperones helps too further regulate the variety of different Hsp90 complexes found in cells.
Funding
Mechanisms of client protein activation and regulation by the Hsp90 molecular chaperone system; G0662; WELLCOME TRUST; 095605/Z11/Z
History
Publication status
- Published
File Version
- Published version
Journal
Biochemistry and Molecular Biology JournalISSN
2471-8084Publisher
iMedPubExternal DOI
Issue
1Volume
3Page range
1-8Department affiliated with
- Biochemistry Publications
Research groups affiliated with
- Genome Damage and Stability Centre Publications
Full text available
- Yes
Peer reviewed?
- Yes