File(s) not publicly available
Replication of damaged DNA in mammalian cells: new solutions to an old problem
journal contributionposted on 2023-06-07, 21:04 authored by Alan LehmannAlan Lehmann
All cells need not only to remove damage from their DNA, but also to be able to replicate DNA containing unrepaired damage. In mammalian cells, the major process by which cells are able to replicate damaged templates is translesion synthesis, the direct synthesis of DNA past altered bases. Crucial to this process is a series of recently discovered DNA polymerases. Most of them belong to a new family of polymerases designated the Y-family, which have conserved sequences in the catalytic N-terminal half of the proteins. These polymerases have different efficiencies and specificities in vitro depending on the type of damage in the template.
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
Full text available