Role%20of%20the%20NF-%CE%BAB%20signaling%20pathway%20AAM.pdf (643.3 kB)
Role of the NF-?B signaling pathway in the pathogenesis of colorectal cancer
journal contribution
posted on 2023-06-21, 06:01 authored by Atena Soleimani, Farzad Rahmani, Gordon FernsGordon Ferns, Mikhail Ryzhikov, Amir Avan, Seyed Mahdi HassanianThe NF-?B signaling pathway is a key regulator of CRC cell proliferation, apoptosis, angiogenesis, inflammation, metastasis, and drug resistance. Over-activation of the NF-?B pathway is a feature of colorectal cancer (CRC). While new combinatorial treatments have improved overall patient outcome; quality of life, cost of care, and patient survival rate have seen little improvement. Suppression of the NF-?B signaling pathway using biological or specific pharmacological inhibitors is a potential therapeutic approach in the treatment of colon cancer. This review summarizes the regulatory role of NF-?B signaling pathway in the pathogenesis of CRC for a better understanding and hence a better management of the disease.
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Publication status
- Published
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- Accepted version
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GeneISSN
0378-1119Publisher
ElsevierExternal DOI
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a14413Volume
726Department affiliated with
- BSMS Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2019-10-01First Open Access (FOA) Date
2020-12-04First Compliant Deposit (FCD) Date
2019-09-27Usage metrics
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