OL_N-AHA photo-rev_2.pdf (558.92 kB)
Selective photoinduced reduction of nitroarenes to n-arylhydroxylamines
journal contribution
posted on 2023-06-07, 07:05 authored by Michael G Kallitsakis, Dimitris I Ioannou, Michael A Terzidis, George KostakisGeorge Kostakis, Ioannis N LykakisWe report the selective photoinduced reduction of nitroarenes to N-arylhydroxylamines. The present methodology facilitates this transformation in the absence of catalyst or additives and uses only light and methylhydrazine. This noncatalytic photoinduced transformation proceeds with a broad scope, excellent functional-group tolerance, and high yields. The potential of this protocol reflects on the selective and straightforward conversion of two general antibiotics, azomycin and chloramphenicol, to the bioactive hydroxylamine species.
History
Publication status
- Published
File Version
- Accepted version
Journal
Organic LettersISSN
1523-7060Publisher
American Chemical SocietyExternal DOI
Issue
11Volume
22Page range
4339-4343Department affiliated with
- Chemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2020-05-22First Open Access (FOA) Date
2021-05-27First Compliant Deposit (FCD) Date
2020-05-22Usage metrics
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