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Simvastatin therapy reduces prooxidant-antioxidant balance: results of a placebo-controlled cross-over trial

journal contribution
posted on 2023-06-08, 13:33 authored by Seyyed M R Parizadeh, Mahmoud R Azarpazhooh, Mohsen Moohebati, Mohsen Nematy, Majid Ghayour-Mobarhan, Shima Tavallaie, Amir A Rahsepar, Maral Amini, Amirhossein Sahebkar, Maryam Mohammadi, Gordon FernsGordon Ferns
Oxidative stress is thought to play an important role in atherogenesis. The statin group of cholesterol-lowering drugs have been shown to reduce cardiovascular events and possess antioxidant properties. We aimed to assess the effects of simvastatin on a novel measure of prooxidant-antioxidant balance (PAB) in dyslipidemic patients. The PAB assay can measure the prooxidant burden and the antioxidant capacity simultaneously in one assay, thereby giving a redox index. We treated 102 dyslipidemic individuals with simvastatin, or a placebo in a double-blind, cross-over, placebo-controlled trial. PAB values were measured before and after each treatment period. Seventy-seven subjects completed the study. We found that statin therapy was associated with a significant reduction in PAB values (P < 0.001). This effect appeared to be independent of the cholesterol-lowering effects of statins. We conclude that serum PAB values are decreased by simvastatin therapy. Regarding previous reports on the elevation of PAB in conditions associated with oxidative stress, the PAB assay, along with other markers of oxidative stress, may be applied to estimate the extent of oxidative stress in patients, assessment of the antioxidative efficacy of medication such as statins and perhaps also for the identification of those individuals who need antioxidant therapy.

History

Publication status

  • Published

Journal

Lipids

ISSN

1558-9307

Publisher

Springer

Issue

4

Volume

46

Page range

333-340

Department affiliated with

  • Division of Medical Education Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-11-19

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