Murray_Carr_2007.pdf (449.64 kB)
Smc5/6: a link between DNA repair and unidirectional replication?
journal contribution
posted on 2023-06-07, 15:15 authored by Jo MurrayJo Murray, Antony CarrAntony CarrOf the three structural maintenance of chromosome (SMC) complexes, two directly regulate chromosome dynamics. The third, Smc5/6, functions mainly in homologous recombination and in completing DNA replication. The literature suggests that Smc5/6 coordinates DNA repair, in part through post-translational modification of uncharacterized target proteins that can dictate their subcellular localization, and that Smc5/6 also functions to establish DNA-damage-dependent cohesion. A nucleolar-specific Smc5/6 function has been proposed because Smc5/6 yeast mutants display penetrant phenotypes of ribosomal DNA (rDNA) instability. rDNA repeats are replicated unidirectionally. Here, we propose that unidirectional replication, combined with global Smc5/6 functions, can explain the apparent rDNA specificity.
History
Publication status
- Published
File Version
- Accepted version
Journal
Nature Reviews Molecular Cell BiologyISSN
1471-0072Publisher
Nature Publishing GroupExternal DOI
Volume
9Page range
177-182Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
Full text available
- Yes
Peer reviewed?
- Yes