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Smc5/6: a link between DNA repair and unidirectional replication?
journal contributionposted on 2023-06-07, 15:15 authored by Jo MurrayJo Murray, Antony CarrAntony Carr
Of the three structural maintenance of chromosome (SMC) complexes, two directly regulate chromosome dynamics. The third, Smc5/6, functions mainly in homologous recombination and in completing DNA replication. The literature suggests that Smc5/6 coordinates DNA repair, in part through post-translational modification of uncharacterized target proteins that can dictate their subcellular localization, and that Smc5/6 also functions to establish DNA-damage-dependent cohesion. A nucleolar-specific Smc5/6 function has been proposed because Smc5/6 yeast mutants display penetrant phenotypes of ribosomal DNA (rDNA) instability. rDNA repeats are replicated unidirectionally. Here, we propose that unidirectional replication, combined with global Smc5/6 functions, can explain the apparent rDNA specificity.
- Accepted version
JournalNature Reviews Molecular Cell Biology
PublisherNature Publishing Group
Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
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