Solubility of chlordiazepoxide,diazepam,and lorazepam in ethanol+water mixtures at 303.2 K
journal contribution
posted on 2023-06-08, 19:23 authored by Abolghasem Jouyban, Javad Shokri, Mohammad Jalali, Davoud Hassanzadeh, William E Acree Jr., Taravat Ghafourian, Ali NokhodchiExperimental solubilities of three benzodiazepines (chlordiazepoxide, diazepam,and lorazepam) in ethanol+water mixtures at 303.2 K are reported.The solubility of drugs was increased with the addition of ethanol and reached the maximum value of a volume fraction of 90 % of ethanol.The Jouyban-Acree model was used to fit the experimental data,and the solubilities were reproduced using previously trained version of the Jouyban-Acree model and the solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the models were 8.6 %,21.9 % and 19.3 %,respectively,for the fitted model,the trained version for ethanol+water mixtures and generally trained version for various organic solvents+water mixtures. © 2009 American Chemical Society.
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- Published
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Journal of Chemical and Engineering DataISSN
0021-9568Publisher
American Chemical SocietyExternal DOI
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7Volume
54Page range
2142-2145Department affiliated with
- Chemistry Publications
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- Yes
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2014-12-21Usage metrics
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