Solubility prediction of paracetamol in water-ethanol-propylene glycol mixtures at 25 and 30°C using practical approaches
journal contribution
posted on 2023-06-08, 19:25 authored by Abolghasem Jouyban, Olduz Azarmir, Shahla Mirzaei, Davoud Hassanzadeh, Taravat Ghafourian, William Eugene Acree Jr, Ali NokhodchiThe solubility of paracetamol in water-ethanol-propylene glycol binary and ternary mixtures at 25 and 30°C was determined using flask shake method. The generated data extended the solubility database for further computational investigations and also was used to assess the prediction capability of the Jouyban-Acree model. A new version of the model was proposed for modeling the solubility data in water-cosolvent mixtures with the cosolvent concentration of <50% which is required in pharmaceutical formulations. The accuracy of the predicted solubilities was evaluated by the mean percentage deviation (MPD) between the predicted and experimental solubilities. The overall MPD of the Jouyban-Acree model and the log-linear model of Yalkowsky for the entire composition range of the cosolvents were 11.0±8.7 and 55.4±17.8%, respectively; the corresponding values for the predicted solubilities in mixtures having a cosolvent concentration of <50% were 12.0±9.1 and 22.0±11.0%. © 2008 Pharmaceutical Society of Japan.
History
Publication status
- Published
File Version
- Published version
Journal
Chemical and Pharmaceutical BulletinISSN
0009-2363Publisher
Pharmaceutical Society of JapanExternal DOI
Issue
4Volume
56Page range
602-606Department affiliated with
- Chemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2015-01-05First Open Access (FOA) Date
2015-01-05First Compliant Deposit (FCD) Date
2015-01-05Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorksRefWorks
BibTeXBibTeX
Ref. managerRef. manager
EndnoteEndnote
DataCiteDataCite
NLMNLM
DCDC