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Stereochemistry of the reaction of the inhibitor ß-chloroalanine with mercaptoethanol, a ß-substitution reaction catalysed by an aminotransferase
journal contribution
posted on 2023-06-07, 23:47 authored by Benjamin Adams, Kenneth J M Beresford, Sheena M Whyte, Douglas W YoungL-Aspartate aminotransferase, a member of the a-family of PLP mediated enzymes, which normally catalyses transamination, has been used to catalyse the ß-substitution reaction of stereospecifically labelled samples of the enzyme inhibitor ß-chloro-L-alanine with 2-mercaptoethanol; the stereochemistry of the products was assigned by independent synthesis, showing that the abnormal substitution reaction proceeds with overall retention of stereochemistry, the usual stereochemical consequence of reactions catalysed by enzymes of the ß-family of PLP mediated enzymes which have low homology with enzymes of the a-family
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- Published
Journal
Chemical CommunicationsExternal DOI
Volume
7Page range
619 - 620ISBN
1359-7345Department affiliated with
- Chemistry Publications
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- No
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- Yes
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2012-02-06Usage metrics
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