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Synaptic mechanisms of adaptation and sensitization in the retina

journal contribution
posted on 2023-06-08, 15:15 authored by Anton Nikolaev, Kin-Mei Leung, Benjamin Odermatt, Leon LagnadoLeon Lagnado
Sensory systems continually adjust the way stimuli are processed. What are the circuit mechanisms underlying this plasticity? We investigated how synapses in the retina of zebrafish adjust to changes in the temporal contrast of a visual stimulus by imaging activity in vivo. Following an increase in contrast, bipolar cell synapses with strong initial responses depressed, whereas synapses with weak initial responses facilitated. Depression and facilitation predominated in different strata of the inner retina, where bipolar cell output was anticorrelated with the activity of amacrine cell synapses providing inhibitory feedback. Pharmacological block of GABAergic feedback converted facilitating bipolar cell synapses into depressing ones. These results indicate that depression intrinsic to bipolar cell synapses causes adaptation of the ganglion cell response to contrast, whereas depression in amacrine cell synapses causes sensitization. Distinct microcircuits segregating to different layers of the retina can cause simultaneous increases or decreases in the gain of neural responses.

History

Publication status

  • Published

Journal

Nature Neuroscience

ISSN

1097-6256

Publisher

Nature Publishing Group

Issue

7

Volume

16

Page range

934-941

Department affiliated with

  • Neuroscience Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2013-06-19

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    University of Sussex (Publications)

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