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Synthesis and Inhibitory Activity of Sialic Acid Derivatives Targeted at Viral Sialate-O- Acetylesterases
journal contributionposted on 2023-06-07, 20:56 authored by Mathew Stanley, Juliane Mayr, Wolfgang Huber, Reinhard Vlasak, Hansjorg Streicher
A series of sialosides modified at the 4- and 9-hydroxy group were synthesised and tested for inhibition of the viral haemagglutinin-esterase activity from various Orthomyxoviruses and Coronaviruses. While no inhibition of the sialate-4-O-acetylesterases from mouse hepatitis virus strain S or sialodacryoadenitis virus was found, a 9-O-methyl derivative displayed inhibitory activity against recombinant sialate-9-O-acetylesterase from influenza C virus.
JournalEuropean Journal of Medicinal Chemistry
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