Synthesis of a thiazole library via an iridium-catalyzed sulfur ylide insertion reaction
journal contributionposted on 2023-06-10, 05:11 authored by Storm Hassel-HartStorm Hassel-Hart, Elisa Speranzini, Sirihathai SrikwanjaiSirihathai Srikwanjai, Euan Hossack, S Mark Roe, Daren Fearon, Daniel Oluwatosin Akinbosede, Stephen Hare, John SpencerJohn Spencer
A library of thiazoles and selenothiazoles were synthesized via Ir-catalyzed ylide insertion chemistry. This process is a functional group, particularly heterocycle-substituent tolerant. This was applied to the synthesis of fanetizole, an anti-inflammatory drug, and a thiazole-containing drug fragment that binds to the peptidyl-tRNA hydrolase (Pth) in Neisseria gonorrheae bacteria.
- Published version
PublisherAmerican Chemical Society (ACS)
Department affiliated with
- Chemistry Publications
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