posted on 2023-06-09, 08:06authored bySupojjanee Sansook, Cory A Ocasio, Iain Day, Graham J Tizzard, Simon Coles, Oleg Fedorov, James Bennett, Jon Elkins, John SpencerJohn Spencer
A series of 3-methylidene-1H-indol-2(3H)-ones substituted with a 5- or 6- pentafluorosulfanyl group has been synthesized by a Knoevenagel condensation reaction of SF5-substituted oxindoles with a range of aldehydes. The resulting products were characterized by x-ray crystallography studies and were tested for biological activity versus a panel of cell lines and protein kinases. Some exhibited single digit nM activity.