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Synthesis, physicochemical properties and antioxidant activity of deferiprone-cyclodextrin conjugates and their iron(III) complexes

journal contribution
posted on 2023-06-08, 12:30 authored by Antonino Puglisi, John SpencerJohn Spencer, Valentina Oliveri, Graziella Vecchio, Xiaole Kong, James Clarke, John Milton
3-Hydroxy-1,2-dimethylpyridin-4(1H)-one (deferiprone) is a successful iron chelator, which has been widely investigated for its activity in mitigating iron overload and in protecting against oxidative stress due to Reactive Oxygen Species (ROS). Herein, we present the synthesis, characterisation, physicochemical properties and antioxidant activity of two novel bioconjugates of ß-cyclodextrin bearing the deferiprone moiety either on the upper rim (1) or on the lower rim (2) of the cyclodextrin and their iron(III) complexes. Protonation and iron stability constants were measured by spectrophotometric titration for the two systems and antioxidant activity studied for both the ligands and the iron(III) complexes.

History

Publication status

  • Published

Journal

Dalton Transactions

ISSN

1477-9234

Publisher

Royal Society of Chemistry

Issue

10

Volume

41

Page range

2877-2883

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-10-22

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