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Synthesis, structural and biological studies of ubiquitin mutants containing (2S, 4S)-5-fluoroleucine residues strategically placed in the hydrophobic core
journal contributionposted on 2023-06-07, 20:31 authored by Dmitriy Alexeev, Paul N Barlow, Stella M Bury, Jean-Damien Charrier, Alan Cooper, David Hadfield, Craig Jamieson, Sharon M Kelly, Robert Layfield, R John Mayer, Helen McSparron, Nicholas C Price, Robert Ramage, Lindsay Sawyer, Bernard A Starkmann, Dusan Uhrin, Jill Wilken, Douglas W Young
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NotesDWY is corresponding author and directed the synthetic work. The work reports the first ubiquitin variants in which selected leucine residues in the hydrophobic core have been replaced by (2S,4S)-5-fluoroleucine residues. Protein X-ray crystallographic, 19F-NMR and biophysical methods were used to show that protein folding was unafected.
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