File(s) not publicly available
TDP1-dependent DNA single-strand break repair and neurodegeneration
journal contributionposted on 2023-06-07, 19:39 authored by Sherif F El-Khamisy, Keith CaldecottKeith Caldecott
DNA single-strand breaks (SSBs) are the commonest DNA lesions that arise spontaneously in living cells. Cells employ efficient processes for the rapid repair of these breaks and defects in these processes appear to preferentially impact on the nervous system, causing human ataxia. Spinocerebellar ataxia with axonal neuropathy (SCAN1) is a human disease that is associated with a defect in repairing certain types of SSBs. Although it is a rare neurodegenerative disease, understanding the molecular basis of SCAN1 will lead to better understanding of the mechanisms that underpin not only neurodegeneration but also cancer.
Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
Full text available