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TRP channels in airway smooth muscle as therapeutic targets
journal contribution
posted on 2023-06-08, 19:47 authored by Martin Gosling, Chris Poll, Su LiCation channels are of fundamental importance in regulating the function of airway smooth cells especially bronchoconstriction in response to spasmogens, and are therefore key players in the pathogenesis of asthma. To date, the identity of these cation channels remains a mystery. However, the recently emerged transient receptor potential (TRP) cation channel family has provided several promising channel candidates. The identification of the key TRP channels involved in regulating airway smooth muscle contractility, and therefore airway tone, could provide new and exciting prospects for the development of novel therapies for the treatment of airway diseases such as asthma. © Springer-Verlag 2005.
History
Publication status
- Published
Journal
Naunyn-Schmiedeberg's Archives of PharmacologyISSN
0028-1298Publisher
Springer-VerlagExternal DOI
Issue
4Volume
371Page range
277-284Department affiliated with
- Chemistry Publications
Full text available
- No
Peer reviewed?
- Yes