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Technical considerations for the generation of novel pseudotyped viruses
journal contribution
posted on 2023-06-09, 14:32 authored by Barnabas King, Nigel J Temperton, Keith Grehan, Simon D Scott, Edward WrightEdward Wright, Alexander W Tarr, Janet M DalyA pseudotyped virus (PV) is a virus particle with an envelope protein originating from a different virus. The ability to dictate which envelope proteins are expressed on the surface has made pseudotyping an important tool for basic virological studies such as determining the cellular targets of the envelope protein of the virus as well as identification of potential antiviral compounds and measuring specific antibody responses. In this review, we describe the common methodologies employed to generate PVs, with a focus on approaches to improve the efficacy of PV generation.
History
Publication status
- Published
Journal
Future VirologyISSN
1746-0794Publisher
Future MedicineExternal DOI
Issue
1Volume
11Page range
47-59Department affiliated with
- Biochemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2018-08-14Usage metrics
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