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The combined use of stereoelectronic control and ring closing metathesis for the synthesis of (-)-8-epi-swainsonine
journal contributionposted on 2023-06-07, 20:36 authored by Philip J Parsons, Adrian J Murray, Peter Hitchcock
A novel and efficient synthesis of (-)-8-epi-swainsonine 2 is reported. Stereocontrolled diol formation from the bicyclic alkene 3 followed by a stereoselective vinylation of the aldehyde and ring closing metathesis gave the indolizidine ring system, which was converted into (-)-8-epi-swainsonine 2. © 2007 Elsevier Ltd. All rights reserved.
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