The effect of engineered mannitol-lactose mixture on dry powder inhaler performance
journal contribution
posted on 2023-06-08, 19:20 authored by Waseem Kaialy, Hassan Larhrib, Gary P Martin, Ali NokhodchiPurpose To co-crystallise mannitol and lactose with a view to obtaining crystals with more favourable morphological features than either lactose or mannitol alone, suitable for use as carriers in formulations for dry powder inhalers (DPIs) using simultaneous engineering of lactose-mannitol mixtures. Methods Mannitol and lactose individually and the two sugars with three different ratios were crystallised/co-crystallised using antisolvent precipitation technique. Obtained crystals were sieved to separate 63-90 µm size fractions and then characterised by size, shape, density and in vitro aerosolisation performance. Solid state of crystallized samples was studied using FT-IR, XRPD and DSC. Results At unequal ratios of mannitol to lactose, the elongated shape dominated in the crystallisation process. However, lactose exerted an opposite effect to that of mannitol by reducing elongation ratio and increasing the crystals' width and thickness. Crystallised ß-lactose showed different anomers compared to commercial lactose (a-lactose monohydrate). Crystallised a- mannitol showed different polymorphic form compared to commercial mannitol (ß-mannitol). Crystallised mannitol:lactose showed up to 5 transitions corresponding to a-mannitol, a- lactose monohydrate, ß-lactose, 5a-/3ß-lactose and 4a-/1ß-lactose. In vitro deposition assessments showed that crystallised carriers produced more efficient delivery of salbutamol sulphate compared to formulations containing commercial grade carriers. Conclusion The simultaneous crystallization of lactose-mannitol can be used as a new approach to improve the performance of DPI formulations. © Springer Science+Business Media, LLC 2012.
History
Publication status
- Published
Journal
Pharmaceutical ResearchISSN
0724-8741Publisher
Springer USExternal DOI
Issue
8Volume
29Page range
2139-2156Department affiliated with
- Chemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2014-12-18Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorksRefWorks
BibTeXBibTeX
Ref. managerRef. manager
EndnoteEndnote
DataCiteDataCite
NLMNLM
DCDC