The effect of glycyrrhizin on the release rate and skin penetration of diclofenac sodium from topical formulations
journal contribution
posted on 2023-06-09, 03:26 authored by Ali Nokhodchi, H Nazemiyeh, Taravat Ghafourian, D Hassan-Zadeh, H Valizadeh, L A S BaharyThe influence of glycyrrhizin extracted from Glycyrrhiza glabra var. glandulifera (licorice roots) on the percutaneous absorption of diclofenac sodium from sodium carboxymethylcellulose (NaCMC) gels or oil-in-water (o/w) emulsion was investigated. Skin permeation experiments were carried out using excised abdominal rat skin. The results showed that the efficiency of glycyrrhizin as an enhancer agent is greater in gel formulations than it is in the emulsions. The enhancer with the concentration of 0.1 w/w in gel increased diclofenac sodium flux value to tenfold compared with the control gel. © 2002 �ditions scientifiques et médicales Elsevier SAS. All rights reserved.
History
Publication status
- Published
Journal
FarmacoISSN
0014-827XPublisher
ElsevierExternal DOI
Issue
11Volume
57Page range
883-888Department affiliated with
- Biochemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2017-11-29Usage metrics
Categories
No categories selectedKeywords
carboxymethylcellulose; diclofenac; Glycyrrhiza extract; glycyrrhizic acid; oil; penetration enhancing agent; wateranimal tissue; article; controlled study; drug absorption; drug concentration; drug efficacy; drug formulation; drug isolation; emulsion; gel; Glycyrrhiza; glycyrrhiza glabra; male; nonhuman; plant root; rat; skin absorption; skin permeabilityAdministrationTopical; Algorithms; Animals; Anti-Inflammatory AgentsNon-Steroidal; ChromatographyHigh Pressure Liquid; Dialysis; Diclofenac; Emulsions; Excipients; Gels; Glycyrrhizic Acid; Male; Rats; Skin Absorption; SpectrophotometryUltraviolet
Licence
Exports
RefWorksRefWorks
BibTeXBibTeX
Ref. managerRef. manager
EndnoteEndnote
DataCiteDataCite
NLMNLM
DCDC