The effect of process parameters on the size and morphology of poly(D, L-Lactide-Co-Glycolide) micro/nanoparticles prepared by an oil in oil emulsion/solvent evaporation technique
journal contribution
posted on 2023-06-08, 19:22 authored by Hamid Mahdavi, Hamid Mirzadeh, Hamed Hamishehkar, Ahmad Jamshidi, Amir Fakhari, Jaber Emami, Abdolhossien Rouholamini Najafabadi, Kambiz Gilani, Mohsen Minaiyan, Mahnaz Najafi, Maryam Tajarod, Ali NokhodchiFor the past few decades, there has been a considerable research interest in the area of biodegradable polymeric micro- and nanoparticles for tissue engineering, regenerative medicine, implants, stents, medical devices, and drug delivery systems. Poly(D, L-lactide-coglycolide) (PLGA) is well-known by its safety in biomedical preparations which has been approved for human use by the FDA. The goal of this study was to evaluate the influence of process parameters on size characteristics of PLGA microparticles prepared by oil in oil (o/o) solvent evaporation technique. This method has been introduced as one of the most appropriate methods for hydrophilic agents. Scanning electron microscopy showed that prepared particles were spherical with smooth surface without aggregation. Particle size varied from 570 nm to 29 µm in different experimental conditions. Stirring speed, polymer concentration, impeller type, and dropping size had a significant effect on the particle size. The polydispersity index of particles showed a strong relationship with the surfactant concentration, impeller type, and dropping size. It was concluded that increasing in temperature up to 50°C or changing in dropping rate has a little effect on reducing the size of PLGA particles. The residual solvent content in the final suspension was less than 0.1 ppm that is in appropriate range for biomedical application. © 2009 Wiley Periodicals, Inc.
History
Publication status
- Published
Journal
Journal of Applied Polymer ScienceISSN
0021-8995Publisher
John Wiley & SonsExternal DOI
Issue
1Volume
116Page range
528-534Department affiliated with
- Chemistry Publications
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- No
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- Yes
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2014-12-19Usage metrics
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